The FDA recently issued a class-wide safety alert for all testosterone-containing medical products. Not only is it associated with abuse and dependence, but it can have “serious adverse outcomes include heart attack, heart failure, stroke, depression, hostility, aggression, liver toxicity, and male infertility. Individuals abusing high doses of testosterone have also reported withdrawal symptoms, such as depression, fatigue, irritability, loss of appetite, decreased libido, and insomnia.”